Infiltrating Immune Cells in the Kidney in Salt-Sensitive Hypertension
نویسنده
چکیده
1 2 Infiltrating Immune Cells in the Kidney in Salt-Sensitive Hypertension 3 and Renal Injury 4 5 David L. Mattson 6 7 8 Department of Physiology, Medical College of Wisconsin, Milwaukee, 9 WI 10 11 12 13 Running title: Immune cells and hypertension 14 15 16 Correspondence to: 17 David L. Mattson 18 Department of Physiology 19 Medical College of Wisconsin 20 8701 Watertown Plank Road 21 Milwaukee, WI 53226 22 Phone: 414-955-8571 23 FAX: 414-955-6546 24 e-mail: [email protected] 25 26 27 Articles in PresS. Am J Physiol Renal Physiol (July 9, 2014). doi:10.1152/ajprenal.00258.2014
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Infiltrating immune cells in the kidney in salt-sensitive hypertension and renal injury.
The importance of the immune system in hypertension, vascular disease, and renal disease has been appreciated for over 50 years. Recent experimental advances have led to a greater appreciation of the mechanisms whereby inflammation and immunity participate in cardiovascular disease. In addition to the experimental data, multiple studies in patients have demonstrated a strong correlation between...
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This study examined mechanisms by which immune cells participate in the development of hypertension and renal disease in Dahl salt-sensitive (SS) rats. Increasing dietary salt from 0.4% to 4.0% NaCl significantly increased renal infiltration of T lymphocytes from 8.8 +/- 1.2 x 10(5) to 14.4 +/- 2.0 x 10(5) cells/2 kidneys, increased arterial blood pressure from 131 +/- 2 to 165 +/- 6 mmHg, incr...
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Accumulating evidence indicates that T cells play an important role in the pathogenesis of hypertension. Here we review the investigations that have shown that T cells are infiltrating the kidney in hypertension. Interstitial accumulation of immune cells is associated with increments in oxidative stress and renal angiotensin II activity that result in the impairment in pressure natriuresis. The...
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Mattson DL, Lund H, Guo C, Rudemiller N, Geurts AM, Jacob H. Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage. Am J Physiol Regul Integr Comp Physiol 304: R407–R414, 2013. First published January 30, 2013; doi:10.1152/ajpregu.00304.2012.—Hypertension and renal damage in Dahl SS rats are associated with increased infiltratin...
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